Many of us are conscious of the fact that slimming is really a mega-dollar industry. With millions, or even millions of people of all ages struggling to shed weight, and very few pharmaceutically effective medications offered to assist them, the desperate public will literally clutch at straws.
Per week sees the launch of any new “miracle” weight loss pill or potion along with a “surefire” diet sure to help believers shed kilos like magic.
Recently weight loss by dr oz took over as the flavour of the year. When you search the net for info on this exotic fruit extract you will certainly be assured that it is finally the miracle we have all been expecting, which will produce dramatic weight-loss. Endorsements by various TV personalities along with other luminaries have included with the allure of Garcinia cambogia slimming products.
According to a recently available local study through the Tshwane University of Technology (TUT) “this small fruit, reminiscent of a pumpkin in appearance, is now most popularly used and widely advertised being a weight-loss supplement”.
The comprehensive overview from TUT implies that studies show that “the extracts along with (-)-hydroxycitric acid (HCA), a primary organic acid aspect of the fruit rind, exhibited anti-obesity activity”. Additionally, it regulates the serotonin levels relevant to satiety, ultimately causing reduced food consumption.
“According to clinical trial reports, Garcinia extracts were helpful to obese individuals oftentimes. Additionally, studies on the toxicity and observations during numerous studies indicate that Garcinia is safe for use. Most of the negative reports are already related to times when multi ingredient formulations were consumed and the effect could stop being related to a unique ingredient.”
The studies does, however, caution against an increase in serotonin, specifically in people who take medicines that are already increasing serotonin levels, like SSRIs. Research into these effects is not conducted.
“Moreover, regulatory authorities should provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the investigation concluded.
Dr Ingrid van Heerden, a registered dietitian, is of opinion we needs to be cautious of how does garcinia work, simply because it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once someone that wants, or needs to shed weight, is hooked on the promise of a slim, sexy figure, they may be sucked in to the deception. If the drops, wafers or powders don’t work, well then it is the fault of the user who did not adhere to one or other often impossible instruction such as “stick to your 500 kcal/day diet” or “drink 5 litres water a day”, never that of the diet program pill.
When eventually science and legislation meet up with the manufacturers, they calmly take product A from the market, change their formulation slightly, change the name to product B, then blithely sell product B using the same advertising gambits as before, raking within the money and pulling the wool over everyone’s eyes once again.
In keeping with the ever-changing slimming product ranges, you will find what one can call “ingredients of year” (sometimes an ingredient will last for only 3 to 6 months, however, many have longer life spans, then of course some are resurrected every two or three years).
We certainly have had apple cider vinegar (that has made many a comeback over the years), green tea extract (which includes earned some merit in scientific research), hoodia (which just fails to have the ability to make the research results that will make it a front-runner), willow bark (or salicylic acid which is useful for pains and aches although not as efficacious for slimming), and good old caffeine (that has a diuretic effect thus helping you lose weight until you replenish this type of water within your body, plus a stimulant effect when taken in big amounts that could be potentially dangerous), to call but a couple of.
While it is perfectly entirely possible that more extensive and well controlled scientific tests will disclose that this extract of Garcinia cambogia containing a chemical called hydroxycitric acid (HCA) can assist weight reduction, our company is at present not yet sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage must achieve really significant weight-loss.
Nevertheless I hear you say: “For once there exists a quantity of scientific research which were completed with Garcinia cambogia, so what’s the trouble?”
Well a number of the studies failed to show any weight loss differences between patients who took Garcinia pills and those who took dummy pills, while other studies did show differences in fat loss with all the subjects taking pills containing Garcinia losing slightly more weight than others that did not (Marquez et al, 2012).
Many of these weight-loss differences were not exactly exciting either, therefore we can’t say without a doubt that Garcinia cambogia does promote fat loss. It also seems likely that this may not be the wonder pill it is actually made to be.
In addition, a lot of the studies conducted to date are already flawed (Critchley, 2013) . What which means is designed for example that in one study the control and experimental subjects were not well matched (i.e. they was without the same starting weight, age, amount of extra fat etc.), during other studies too few subjects were utilized to the leads to be significant.
To the outcomes of studies to get plausible one has to compare “apples with apples” (i.e. well-matched subjects and controls) and also you need not only a number of subjects to create the identical result.
About the positive side, we can easily claim that there is some evidence that Garcinia cambogia products may aid fat loss over a period of 12 weeks. No research has been conducted for much longer periods as yet (Marquez et al, 2012), which is also viewed as a drawback.
Addititionally there is at the moment an argument regarding the safety of pills containing Garcinia cambogia – one selection of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez and his awesome coworkers (2012) suggest that “at the doses usually administered, no differences have already been reported in terms of adverse reactions or adverse events (those studied) in humans between individuals addressed with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the United States has published a stern warning concerning the hepatotoxicity of a diet product called “Hydroxycut”, containing Garcinia cambogia. The author collected case reports of patients who developed liver toxicity linked to the previously listed weight reduction product.
Evidently approximately one million units of this hydroxycitric acid product are sold annually in the USA. The patients who developed hepatotoxicity reported symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the volume of hepatotoxicity cases reported were only a few, Lob indicates that monitoring of adverse events linked to dietary supplements such as these weight reduction products is woefully inadequate in the united states (as is the case in many other countries, including South Africa), with all the FDA only receiving about 1% of such negative reports.
Based on Lob (2009), the Poison Control Centres in the us are more inclined to receive reports of adverse events linked to vitamin supplements but are not equipped to coordinate such findings.
He cites the truly sobering example of a product or service called “Metabolife 356″ that has been sold as a weight loss supplement in America. Lob’s states that the manufacturers received 14 000 reports during a period of five years that documented “serious adverse events related to their ephedra-containing product” which dexrpky17 cardiac arrest, strokes, convulsions and fatalities.
The makers failed to inform the FDA or another US government authority of such reports. As astounding because this may appear, manufacturers of nutritional supplements usually are not required to meet any one of the specifications which can be strictly enforced with regards to food and pharmaceutical products (medicines), for them to utilize this “ethical loophole” to never publish reports of negative and harmful events.
Eventually these events arrived at light and ephedra-containing products for slimming and other uses were banned in the united states.
The implication contain in Lob’s warning is the fact that HCA or Garcinia cambogia extract may also be potentially toxic unless sufficient, reliable evidence for the contrary is created available.
With the present moment, we have no idea enough about slimming products which contain what are the side effects to garcinia cambogia to freely recommend its use. I usually are in agreement with Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled numerous studies to assess the evidence located on the efficacy of current vitamin supplements accustomed to control appetite or weight.
These authors concluded that “According towards the finding with this systematic review, evidence is not really convincing in demonstrating that a majority of nutritional supplements used as appetite suppressants for weight-loss in dealing with obesity work well and safe.”
Basically we wait around for more extensive and conclusive evidence obtained with larger numbers of well-matched test subjects treated for longer periods with all the “gold standard” of double blind randomised controlled clinical trials, rather stay away from any weight-loss supplement that is not tested thoroughly.